Journal article
Muscle Protein Synthesis after Protein Administration in Critical Illness
LAS Chapple, IWK Kouw, MJ Summers, LM Weinel, S Gluck, E Raith, P Slobodian, S Soenen, AM Deane, LJC van Loon, MJ Chapman
American Journal of Respiratory and Critical Care Medicine | AMER THORACIC SOC | Published : 2022
Abstract
Rationale: Dietary protein may attenuate the muscle atrophy experienced by patients in the ICU, yet protein handling is poorly understood. Objectives: To quantify protein digestion and amino acid absorption and fasting and postprandial myofibrillar protein synthesis during critical illness. Methods: Fifteen mechanically ventilated adults (12 male; aged 50 ± 17 yr; body mass index, 27 ± 5 kg⋅m-2) and 10 healthy control subjects (6 male; 54 ± 23 yr; body mass index, 27 ± 4 kg⋅m-2) received a primed intravenous L-[ring-2H5]-phenylalanine, L-[3,5-2H2]-tyrosine, and L-[1-13C]-leucine infusion over 9.5 hours and a duodenal bolus of intrinsically labeled (L-[1-13C]-phenylalanine and L-[1-13C]-leuci..
View full abstractGrants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
Supported by the National Health and Medical Research Council project grant APP1144496. L.-a.S.C. has been supported by a European Society for Clinical Nutrition and Metabolism Research Fellowship (2018) and a National Health and Medical Research Council Early Career Fellowship (2019-2022). The Royal Adelaide Hospital provided infrastructure and administrative support.